For monitored anesthesia care sedation. For initiation of monitored anesthesia care sedation. Continuous Intravenous Infusion dosage Adults and Adolescents 17 years and older 100 to 150 mcg/kg/minute (6 to 9 mg/kg/hour) IV infusion over 3 to 5 minutes in healthy adults age 54 years or less, titrated to clinical response and followed immediately by maintenance dosing. Reduce the dosage to approximately 80% of the usual adult dosage in elderly, debilitated, neurosurgical, or ASA-PS III or IV patients according to their condition, responses, and changes in vital signs. Closely monitor cardiorespiratory function.
Intermittent Intravenous dosage Adults and Adolescents 17 years and older 0.5 mg/kg slow IV injection over 3 to 5 minutes in healthy adults age 54 years or less, titrated to clinical response and followed immediately by maintenance dosing. Reduce the dosage to approximately 80% of the usual adult dosage in elderly, debilitated, neurosurgical, or ASA-PS III or IV patients according to their condition, responses, and changes in vital signs; avoid rapid (single or repeated) bolus dose administration in these patient populations. Closely monitor cardiorespiratory function.
For maintenance of monitored anesthesia care sedation. Continuous Intravenous Infusion dosage Adults and Adolescents 17 years and older 25 to 75 mcg/kg/minute (1.5 to 4.5 mg/kg/hour) IV continuous infusion is required in most healthy adults age 54 years or less during the first 10 to 15 minutes of maintenance. Subsequently decrease the infusion rate to 25 to 50 mcg/kg/minute IV and adjust according to clinical response, allowing approximately 2 minutes for onset of peak drug effect. Titrate infusion rates downward in the absence of clinical signs of light sedation until mild responses to stimulation are obtained in order to avoid administration at rates higher than are clinically necessary. Reduce the dosage and rate of administration to approximately 80% of the usual adult dosage in elderly, debilitated, neurosurgical, or ASA-PS III or IV patients according to their condition, responses, and changes in vital signs. Closely monitor cardiorespiratory function.
Intermittent Intravenous dosage Adults and Adolescents 17 years and older A variable rate intravenous infusion is preferred over an intermittent bolus technique. If bolus dosing is utilized, administer 10 or 20 mg/dose IV as incremental boluses in healthy adults age 54 years or less. Reduce the dosage to approximately 80% of the usual adult dosage in elderly, debilitated, neurosurgical, or ASA-PS III or IV patients according to their condition, responses, and changes in vital signs; avoid rapid (single or repeated) bolus dose administration in these patient populations. Titrate dosage to clinical effect. Closely monitor cardiorespiratory function.